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Giovanni Mattaliano

Random distribution Radiographics. Langerhans cell histiocytosis (LCH) is an idiopathic disease characterized in its early stages by granulomatous nodules containing Langerhans histiocytes and eosinophils. In the differential diagnosis there is overlap between Common additional findings are an enlarged heart and pleural fluid. Thorax. On the left a patient with both septal thickening and ground glass opacity in a patchy distribution. Emphysema radiology Emphysema Radiology Ke Definition and Etiology Emphysema is defined as a condition of the lung characterized by abnormal, permanent enlargement of the airspaces distal to the terminal bronchiole, accompanied by destruction of their walls. Any lucency >10 mm should be referred to as subpleural blebs/bullae (synonymous) 3. North Am. When you think of the causes of consolidation, think of 'what is replacing the air in the alveoli'? In patients with a perilymphatic distribution, nodules are seen in relation to pleural surfaces, interlobular septa and the peribronchovascular interstitium. Takasugi JE, Godwin JD. When they are confluent, HRCT shows diffuse ground glass. We will discuss the following subjects: Secondary lobule Crazy paving was thought to be specific for alveolar proteinosis, but is also seen in many other diseases such as pneumocystis carinii pneumonia, bronchoalveolar carcinoma, sarcoidosis, Centrilobular area is the central part of the secundary lobule. 5. Idiopathic pulmonary fibrosis (IPF), accounts for more than 60% of the cases of UIP. There are patchy non-segmental consolidations in a subpleural and peripheral distribution. This case is one of the possible patterns of nonspecific interstitial pneumonia (NSIP). Even fibrosis as in UIP, NSIP and long standing sarcoidosis can replace the air in the alveoli and cause consolidation. 9. Members of the Fleischner Society compiled a glossary of terms for thoracic imaging that replaces previous glossaries published in 1984 and 1996 for thoracic radiography and computed tomography (CT), respectively. Look at expiratory scans for air trapping, Infection (PCP, viral, Mycoplasma, bacterial), Pulmonary edema due to heart failure or ARDS, Lung cysts (LAM, LIP, Langerhans cell histiocytosis), Irreversible destruction of alveolar walls in the centrilobular portion of the lobule, Upper lobe predominance and uneven distribution, In alpha-1-antitrypsin deficiency, but also seen in smokers with advanced emphysema, Adjacent to the pleura and interlobar fissures, Can be isolated phenomenon in young adults, or in older patients with centrilobular emphysema, In young adults often associated with spontaneous pneumothorax, lack of normal tapering with visibility of airways in the peripheral lung, associated atelectasis and sometimes air trapping, Inhaled particles: pneumoconiosis (silica or coal), Smoking related diseases (centrilobular emphysema, Lymphangitic spread of carcinoma - often unilateral. Lymphangitic carcinomatosis with hilar adenopathy. Sarcoidosis: nodules with perilymphatic distribution, along fissures, adenopathy. Notice the centrilobular artery in the center. Emphysema is one of a heterogeneous group of pathological processes forming chronic obstructive pulmonary disease and is itself a relatively vague term encompassing a number of entities and morphological patterns including: The three morphologic subtypes of emphysema are named according to their relationship to the secondary pulmonary lobule. Publicationdate 25-3-2020 The CO-RADS classification is a standardized reporting system for patients with suspected COVID-19 infection developed for a moderate to high prevalence setting. 1989 Mar. 170(3 Pt 1):629-35. . The location of the abnormalities in ground glass pattern can be helpfull: The ground glass pattern itself is rather unspecific. 1999;54 (5): 379. Foster WL, Gimenez EI, Roubidoux MA et-al. In end stage sarcoidosis we will see fibrosis, which is also predominantly located in the upper lobes and perihilar. Bronchiectasis caused by primary airway disease should be differentiated from tracion bronchiectasis as a result of fibrosis. Learn more about how emphysema affects you and how it’s treated. 2010/04 - * Assistant Professor, Radiology, University Hospital, Faculty of Medicine, Saga University Field of Specialization Radiation science Research Topics and Results Gastric emphysema in chemosensitive gastric diffuse The diagnosis of bronchiectasis is usually based on a combination of the following findings: A signet-ring sign represents an axial cut of a dilated bronchus (ring) with its accompanying small artery (signet). Not Avail. Sarcoid end-stage with massive fibrosis in upper lobes presenting as areas of consolidation. Patients with COP typically present with a several-month history of nonproductive cough. On the left another typical case of sarcoidosis. Sarcoidosis end-stage: consolidation as a result of massive fibrosis perihilar and in upper lobes. This is called the air bronchogram. Cavities frequently arise within a mass or an area of consolidation as a result of necrosis. We will discuss them here, because the prominent feature is the lucency. The majority of patients are young or middle-aged adults presenting with nonspecific symptoms of cough and dyspnea. In the proper clinical setting suspect active endobronchial spread of TB. The random distribution is a result of the hematogenous spread of the infection. The secondary lobule is supplied by a small bronchiole or terminal bronchiole in the center, which is parallelled by the centrilobular artery. Chest radiology, the essentials. Like in COP we see patchy non-segmental consolidations in a subpleural distribution. There was a marked eosinophilia in the peripheral blood. Nodules can usually be seen to involve the pleural surfaces and fissures, but lack the subpleural predominance often seen in patients with a perilymphatic distribution. Cavities are defined as radiolucent areas with a wall thickness of more than 4mm and are seen in infection (TB, Staph, fungal, hydatid), septic emboli, squamous cell carcinoma and Wegener's disease. In this article a practical approach is given for the interpretation of HRCT examinations. 1. Bronchiectasis is defined as localized bronchial dilatation. Parr DG, Sevenoaks M, Deng C, Stoel BC, Stockley RA. Detection of emphysema progression in alpha 1-antitrypsin deficiency using CT densitometry; methodological advances. Not suprisingly, there is a big overlap in the causes of ground-glass opacity and consolidation and some diseases may present with both areas of ground-glass and consolidation. Collins J, Stern EJ. Lymphangiomyomatosis is a rare disease characterized by progressive proliferation of spindle cells, resembling smooth muscle. In patients with LCH, the pathologist may find LCH, but also areas of emphysema, respiratory bronchiolitis and even fibrosis. LCH in the early phase is a nodular disease (figure). The weight loss is suggestive of a malignant disease. An upper lobe predominance in the size and number of cysts is common. Suga K, Tsukuda T, Awaya H et-al. Thickening of the lung interstitium by fluid, fibrous tissue, or infiltration by cells results in a pattern of reticular opacities due to thickening of the interlobular septa. Tree-in-bud describes the appearance of an irregular and often nodular branching structure, most easily identified in the lung periphery. On the left a patient who had a CT to rule out pulmonary embolism. Check for errors and try again. Paraseptal emphysema focal or diffuse consolidation (30%) as in this case. J Thorac Dis. Patients with emphysema are hypocapnic and are often referred to as "pink puffers". It was described in earlier years as Bronchiolitis-obliterans-organizing pneumonia (BOOP). Filling of the alveolar spaces with pus, edema, hemorrhage, inflammation or tumor cells. sarcoid, lymphangitic carcinomatosis, pulmonary edema). The most common cause has historically been, and unfortunately continues to be, smoking. This finding is helpful in distinguishing PLC from other causes of interlobular septal thickening like Sarcoidosis or cardiogenic pulmonary edema. Temporary bronchiolitis with air trapping is seen in: On the left a patient with ground glass pattern in a mosaic distribution. Paraseptal emphysema is localized near fissures and pleura and is frequently associated with bullae formation (area of emphysema larger than 1 cm in diameter). Here two images af a patient with GGO as the dominant pattern. Just as asthma is no longer grouped with COPD, the current definition of COPD put forth by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) also no longer distinguishes between emphysema and chronic bronchitis. Basic Interpretation Unlike perilymphatic and random nodules, centrilobular nodules spare the pleural surfaces. 8. Cardiogenic pulmonary edema generally results in a combination of septal thickening and ground-glass opacity. There are also additional findings, that support this diagnosis like mediastinal lymph nodes and a nodular lesion in the left lung, that probably represents a metastasis. It takes many years of smoking to develop COPD and as such typically patients are older adults. In sarcoidosis the common pattern is right paratracheal and bilateral hilar adenopathy ('1-2-3-sign'). Lymphangiomyomatosis occurs only in women, usually of child-bearing age, between 17 and 50 years. When it extends beyond the centrilobular area to the edge of the secondary lobule, it may look as if it is cystic with walls. Bronchoalveolar carcinoma can also look like this. In the other 20-40% of the cases the lung disease is not treatable and the ground-glass pattern is the result of fibrosis. The most peripheral nodules are centered 5-10mm from fissures or the pleural surface. It is predominantly a disease of middle to late life owing to the cumulative effect of smoking and other environmental risk factors. An award-winning, radiologic teaching site for medical students and those starting out in radiology focusing on chest, GI, cardiac and musculoskeletal diseases containing hundreds of lectures, quizzes, hand-out notes This article focuses on panlobular emphysema, paraseptal emphysema, and in particular centrilobular emphysema. Many cases are idiopathic, but OP may also be seen in patients with pulmonary infection, drug reactions, collagen vascular disease, Wegener's granulomatosis and after toxic-fume inhalation. Notice the nodules along the fissures indicating a perilymphatic distribution (red arrows). Under normal conditions only a few of these very thin septa can be seen. Organizing pneumonia (OP) It traditionally affected more men than women, but with increased smoking and environmental risk factor exposure among women, the incidence is now equal between the sexes. In fibrosis there will be other signs of fibrosis like honeycombing or traction bronchiectasis. ISBN:0323296351. Honeycombing is the typical feature of usual interstitial pneumonia (UIP). Kemp SV, Polkey MI, Shah PL. It is also associated with smoking and can lead to the formation of subpleural bullae and spontaneous pneumothorax 3. less often, an airway disease associated primarily with mucus retention like allergic bronchopulmonary aspergillosis and asthma. In most cases small nodules can be placed into one of three categories: perilymphatic, centrilobular or random distribution. Giant bullae occasionally cause severe compression of adjacent lung tissue. Radiology Department of the Rijnland Hospital, Leiderdorp and the Academical Medical Centre, Amsterdam, the Netherlands Publicationdate 2006-12-24 In this article a practical approach is given for the interpretation of HRCT examinations. J Magn Reson Imaging. Prognosis is worse in patients who continue to smoke, are alpha-1-antitrypsin deficient, have low FEV1 at time of diagnosis, or have other comorbidities (e.g. (2016). Allergic bronchopulmonary aspergillosis is a lung disease occurring in patients with asthma or cystic fibrosis, triggered by a hypersensitivity reaction to the presence of Aspergillus fumigatus in the airways. Robbins & Cotran Pathologic Basis of Disease: Expert Consult - Online: Expert Consult - Online. On the left a case of chronic eosinophilic pneumonia. They are sometimes called acinair nodules. This combination of findings is called 'crazy paving'. Lymphangiomyomatosis (LAM): uniform cysts in woman of child-bearing age; no history of smoking; adenopathy and pleural effusion; sometimes pneumothorax. It is predominantly located in the upper zones of each lobe (i.e. Radiol. When we study patients with HRCT, we have to realize that we are looking at a selected group of patients. Common diseases like pneumonias, pulmonary emboli, cardiogenic edema and lungcarcinoma are already ruled out. Subpleural honeycomb cysts typically occur in several contiguous layers. Normal lung appearing relatively dense adjacent to lung with air-trapping. It is also described as 'unresolved pneumonia'. Smooth septal thickening is usually seen in interstitial pulmonary edema (Kerley B lines on chest film); lymphangitic spread of carcinoma or lymphoma and alveolar proteinosis. They include: 1. cigarette smoking 2. industrial exposure (e.g. It should be noted, however, that there is relatively poor correlation between autopsy-proven emphysema, pulmonary function test abnormalities and CT with 20% of pathology-proven cases not being evident on CT and 40% of patients with abnormal CT having normal pulmonary function tests. ( 5 ) thickening in the chapter on the left another patient ground. About 1-2 cm and is most severe in the lower lobes lung attenuation or air-filled lesions on conventional radiography a! Lungbiopsy, when honeycombing is defined by the centrilobular region peripheral part of the underlying of. 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